| Species reactivity |    Reacts with: Mouse, Rat, Human    Predicted to work with: Horse, Guinea pig,   Dog, Pig | 
        
            | Cellular localization |  Secreted. VEGF121 is acidic and freely   secreted. VEGF165 is more basic, has  heparin-binding properties and, although   a signicant proportion remains cell-  associated, most is freely secreted.   VEGF189 is very basic, it is cell-associated  after secretion and is bound   avidly by heparin and the extracellular matrix,  although it may be released   as a soluble form by heparin, heparinase or  plasmin |